Iran News ...


10/28/08

Drug Delivery Nanosystem Containing Ibuprofen developed at Iran's Amir Kabir University

Source: The Iraninan Nanotechnology Initiative

Sarah Shafi, an Amir Kabir University researcher, synthesized a layered double hydroxide that can be applied in controlled drug delivery.

"Layered double hydroxide can be used in a variety of industries; one of the most significant ones is in controlled drug delivery systems. In the project we could synthesize Ibuprofen-LDH hybrid and analyze its releasing behavior using co-deposition and anion exchange", she reported in an interview with Nanotechnology Initiatives website.

It is worth mentioning that, according to Ms. Shafi, the existing drug delivery systems are based on polymers and release high levels of drugs to the body which causes side effects. However, the new system is composed of nanoclay layers that can deliver low levels of drugs more efficiently. The system can carry the drug molecules within the nanoclay layers and release in the patient's body, which increases solubility in the stomach and eliminates drug side effects. Ibuprofen has been used as a sample while the system can be used to treat cancers. The system's nanoscale layers are highly potential in delivering Taxole and MTX (anticancer drugs with very low solubility) and increasing their solubility.

The project was supervised by Dr. Solati and is among the priorities of nanotechnology in Iran. Sarah Shafi, an Amir Kabir University researcher, synthesized a layered double hydroxide that can be applied in controlled drug delivery.

... Payvand News - 10/28/08 ... --



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